Chris Cheetham will retire from the industry after 17 years as global chief investment officer of HSBC Global Asset Management.
Cheetham, who has been working in the investment industry for 40 years, will remain with the company while it searches for his successor in order to "complete a smooth transition of responsibilities".
His successor will be announced in "due course", HSBC GAM said in a statement.
The news comes less than a week after colleague Richard Deutsch left HSBC Global Asset Management after eight years as head of global credit research to join Amundi.
Sridhar Chandrasekharan, global CEO of HSBC GAM, thanked Cheetham for his "significant contributions to the business".
Chandrasekharan added: "Chris has led the creation of a global investment platform, the expansion into new asset classes and the nurturing of a strong investment team, all of which has helped us deliver a high standard of service to our clients globally."
Cheetham joined the firm in 2003 as global CIO, after three years in the same job at AXA Investment Managers. He joined AXA Group in 1996, holding numerous roles including CEO of AXA Sun Life Asset Management.
He was appointed non-executive director of the Pension Protection Fund in April 2018 and serves as a trustee of the Mineworkers' Pension Scheme.