Vanguard is set to open an office in Ireland in Q1 next year in an effort to meet its growing oversight and administration responsibilities with regards to Ireland-domiciled assets.
The world's second largest asset manager has received approval from the Central Bank of Ireland regarding a UCITS license.
Vanguard has around $115bn assets under management (AUM) domiciled in Ireland across its UCITS fund range.
Sean Hagerty, head of Europe at Vanguard, stressed the move was part of the firm's plans to lower the "cost and complexity" of investing across Europe and the UK.
Ireland has proven a popular place for fund managers looking to open offices on the continent amid continued Brexit uncertainty.
So far, Aberdeen Standard Investments, JP Morgan and Legal & General Investment Management have opened offices in Dublin due to pressures surrounding the UK's exit from the European Union.
However, Vanguard has denied that the location choice has been driven by Brexit pressures, saying an Irish office has been in the works for some time.
Hagerty said: "Clearly, in the present environment, there will be speculation relating to Brexit. The opening of our Irish office is something we have been considering for a number of years, and should be understood as part of our wider, long-term commitment to lowering the cost and complexity of investing across continental Europe and the UK."
He added: "The opening of an office in Dublin is an important step in meeting our growing fund oversight and administration responsibilities in respect of our Ireland-domiciled product range.
"Our Irish office is also intended to help us build on our existing relationships with business partners, policy makers and the regulators that oversee our Irish-domiciled UCITS range.
"We are strong believers in UCITS as an effective, widely recognised and respected governance framework for both mutual funds and ETFs."